A Randomized Controlled Trial on Effect of Preoperative Immunonutrition Versus Standard Oral Nutrition in Patient Undergoing Colorectal Surgery.

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a randomised controlled clinical trial . The investigators aim to compare the effects of preoperative immune modulating enteral nutrition and standard oral nutrition supplement on clinical outcomes of the patients undergo colorectal cancer surgery. The main questions it aims to answer are: 1. Does immunonutrition preoperatively facilitate earlier return of Gastrointestinal function? 2. Does immunonutrition significantly reduce risk of post-operative surgical site infections? 3. Does immunonutrition significantly reduce duration of hospital stay in patients undergoing colorectal surgery? Immunonutrition can be defined as modulation of either the activity of the immune system, or modulation of the consequences of activation of the immune system, by nutrients or specific food items fed in amounts above those normally encountered in the diet. Oral IMPACT is readily available immunonutrition consist of 3.3 g of arginine,0.8 g of omega-3 fatty acids and 3.0 g of nucleotides per servings. Nutren Optimum is a balanced nutritional supplement that enhance body natural defence and support recovery during illness. However, it does not consist all the component of immunonutritons. Hence , Oral IMPACT will be used as study sample on experimental arm whereas Nutren optimum will be used as study sample on control arm. Partipicant will be randomised into this two arm and then they will consume the respective arm study material for total of 7 days preoperatively. Data will be collected in post operative period and will be analysed.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age is at least 18 years old

• All cases posted for Laparoscopic elective colorectal surgery

Locations
Other Locations
Malaysia
Hospital Universiti Sains Malaysia
RECRUITING
Kubang Kerian
Contact Information
Primary
Manivaasan Pannirselvam, Dr
manivaasan.p@student.usm.my
+60102258767
Backup
Wong Pak Kai ( Michael), Dr
michaelpkwong@usm.my
+609-7676779
Time Frame
Start Date: 2023-09-26
Estimated Completion Date: 2024-09-25
Participants
Target number of participants: 58
Treatments
Experimental: Oral Impact
Immunonutrition enriched with omega-3 fatty acids, arginine, nucleotides, and soluble fibre. Main source of protein is arginine and casein.
Active_comparator: Nutren Optimum
A balanced nutritional supplement that enhance body natural defence and support recovery during illness.
Related Therapeutic Areas
Sponsors
Leads: Hospital Universiti Sains Malaysia

This content was sourced from clinicaltrials.gov